N acetylcysteine gambling

Evidence to date does not support the efficacy for N-acetylcysteine in treating addictions to gambling, methamphetamine, or nicotine, As such, since N-acetylcysteine is a prodrug of glutathione, it may modulate all of the aforementioned receptors as well. – Glutathione also modulates the NMDA receptor by acting at the redox site. L-cysteine . Sep 11,  · University of Minnesota researchers have discovered that N-acetyl cysteine, a common amino acid available as a health food supplement, may help curb pathological gamblers’ addiction. Background: Although pathological gambling (PG) is relatively common, pharmacotherapy research for PG is limited. N-acetyl cysteine (NAC), an amino acid, seems to restore extracellular glutamate concentration in the nucleus accumbens and therefore offers promise in reducing addictive behavior.

An Open-Label Study of N-Acetyl Cysteine in Pathological Gambling

This ability led researchers to believe NAC could have a promising role to play in minimizing addictive behavior. A large-scale study investigating NAC as an adjunctive therapy for schizophrenia has been conducted, 42 which employed a mg, bi-daily regimen compared with placebo in addition to existing medication over 6 months. Arsenic poisoning Dimercaprol Succimer. Accident and Emergency Nursing. Pathological gambling In an open-label study involving 29 participants with a confirmed pathologic addiction to gambling, Grant and colleagues 37 administered mg titrated dose of NAC over 8 weeks. Interestingly, they also reported a decline in compulsive feelings regarding their marijuana use.

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There is an expanding field of research investigating the benefits of alternatives to current pharmacological therapies in psychiatry. N -acetylcysteine NAC is emerging as a useful agent in the treatment of psychiatric disorders. Like many therapies, the clinical origins of NAC are far removed from its current use in psychiatry.

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Whereas the mechanisms of NAC are only beginning to be understood, it is likely that NAC is exerting benefits beyond being a precursor to the antioxidant, glutathione, modulating glutamatergic, neurotropic and inflammatory pathways. This review outlines the current literature regarding the use of NAC in disorders including addiction, compulsive and grooming disorders, schizophrenia and bipolar disorder.

N -acetylcysteine has shown promising results in populations with these disorders, including those in whom treatment efficacy has previously been limited. The therapeutic potential of this acetylated amino acid is beginning to emerge in the field of psychiatric research.

N -acetylcysteine is now widely used as a mucolytic and in the treatment of HIV, and it has reported efficacy in chronic obstructive pulmonary disease and contrast-induced nephropathy. Glutathione is the primary endogenous antioxidant. Glutathione neutralizes reactive oxygen and nitrogen species from the cell through both direct and indirect scavenging.

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If it is clinically necessary to modify this schedule e. Subjects will start no other psychotropic medications during the study but may continue on previously prescribed psychotropic medications if on a stable dose for 3 months prior to study entry. Psychotherapy of any form including cognitive-behavioral therapy will not be initiated during the study but subjects may continue with current psychotherapy if they have been undergoing therapy for at least three months prior to study entry.

Medication side effects will be evaluated at each study visit. A tablet count will be kept for each dose of medication taken. The following instruments will be completed at the screening visit and periodically throughout the study: Safety evaluations, including pulse and blood pressure, and assessment of side effects will be done at each visit. Single Group Assignment Masking: None Open Label Primary Purpose: January Actual Study Completion Date: Talk with your doctor and family members or friends about deciding to join a study.

To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. Ages Eligible for Study: All Accepts Healthy Volunteers: Yes Criteria Inclusion Criteria:. Hide glossary Glossary Study record managers: Search for terms x. Warning You have reached the maximum number of saved studies An Open-Label Study of N-Acetyl Cysteine in Pathological Gambling The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.

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Listing a study does not mean it has been evaluated by the U. Read our disclaimer for details. Drug Information available for: Information from the National Library of Medicine Choosing to participate in a study is an important personal decision.

Unstable medical illness on physical examination History of seizures Myocardial infarction within 6 months Current pregnancy or lactation, or inadequate contraception in women of childbearing potential Clinically significant suicidality Lifetime history of DSM-IV bipolar disorder type I, dementia, or schizophrenia or any other DSM-IV psychotic disorder Current or recent past 3 months DSM-IV substance abuse or dependence Illegal substance within 2 weeks of study initiation Initiation of psychotherapy or behavior therapy from a mental health professional within 3 months prior to study baseline Previous treatment with N-Acetyl Cysteine.


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